Objectives: The purpose of this study was to examine the Path modeling effect among depression, Post-Traumatic Stress Disorders (PTSD), resilience, and social support on the quality of life (QoL) of natural disaster victims. Methods: This is a cross-sectional study with 1,979 disaster victims’ cases by using the 4th Disaster victims panel survey in Korea. Data were collected from october 2018 to december 2018 and analyzed using regression analysis and path�way analysis. Results: Perceived health, depression, social support, PTSD, resilience, and QoL showed significant correlations. PTSD was directly affected by depression and QoL was affected by PTSD. Social support was directly affected by depression and resilience was also directly affected by depression. QoL was affected by social support and resilience. Conclusion: This analysis highlighted that the relation between lower depression and QoL was mediated by greater social support and resilience and lower degree of PTSD. These results suggest that community health interventions and education that incorporate social support and resilience may improve the quality of life of natural disaster victims.